Types of collagen occurring in the human organism.

About 20 types of collagen are present in living organisms. The most important ones are listed below, together with where they occur.

Collagen I. , ligaments, bone, cornea, teeth, fibrous cartilage, womb and the inter - vertebral disc.

Collagen II. Cartilage, vitreous cells and intervertebral disc.

Collagen III. Womb, skin, intestines, heart membranes, jaws.

Collagen IV. Membranes.

Collagen V. Cornea, bone, cartilage.

Collagen VI. Stomach membrane, skin and cartilage.

Collagen VII. Skin, lungs, cornea.

Collagen VIII. Unknown, produced in body cells.

Collagen IX. Cartilage.

Collagen X. Produces chronodrocites during ossification.

Collagen XI. Cartilage, intervertebral cartilage and bone enamel.

Collagen XII. Ligaments, tendons and tooth enamel.

The following table presents the occurrence in organs of a selected collagen type. The results of immunologic studies show that the synthesis of this collagen type in skin takes place not only in fibroblasts, but also in the keratinocyte layer - epidermis.

Skin

Collagen produced by the keratinocyte layer freely moves in the extracellular space. Basement membrane and proper skin are built of type I collagen. The cited literature shows that the transdermal penetration of hydrated collagen with 1.5 nm diameter to extracellular space is obvious.

Skin is the largest organ on our body, made up of several different components, including water (read more), protein, lipids and different minerals and chemicals. It takes a lot to protect you, too: just about six pounds (that’s roughly how much your skin would weigh by itself). Throughout your life your skin will change, for better or worse. Proper care and treatment is essential to maintaining the health and vitality of this crucial protection.

It's easy to skip that glass of water (read more) during the haste of your daily routines or to cleanse yourself. But over time, those bad habits can take a toll on your skin.

Over the course of your life, you should pay attention to all parts of your skin. Familiarize yourself with it, so you'll notice any changes that might occur, such as different moles or patches that might require further attention.

This information serves as an overview only, and should not replace a professional's advice. The skin's structure.

Epidermis: The outer layer

It's the thinnest layer, but it's responsible for protecting you from the harsh environment, with five layers of its own:

stratum germinativum, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.

The epidermis also hosts different types of cells:

keratinocytes, melanocytes and Langerhans cells.

Keratinocytes produce the protein known as keratin, the main component of the epidermis.

Melanocytes produce your skin pigment, known as melanin.

Langerhans cells prevent things from getting into your skin.

Dermis: The middle layer

This is the layer responsible for wrinkles. The dermis is a complex combination of blood vessels, hair follicles, and sebaceous (oil) glands. Here, you'll find collagen and elastin, two proteins necessary for skin health because they offer support and elasticity. Fibroblasts are the cells you'll find in this layer, because they synthesize collagen and elastin. This layer also contains pain and touch receptors.

Hypodermis: The fatty layer

Reduction of tissue in this layer is what contributes to sagging skin. This layer is also known as the sub cutis. It hosts sweat glands, and fat and collagen cells, and is responsible for conserving your body's heat and protecting your vital inner organs.

The skin's proteins:

Collagen: It's the most abundant protein in the skin, making up 75 percent of your skin. This is also your fountain of youth, for it's responsible for warding off wrinkles and fine lines. Over time, environmental factors and aging diminish your body's ability to produce collagen.

Elastin: Think elastic. This protein is found with collagen in the dermis. It's another protein, responsible for giving structure to your skin and organs. As with collagen, elastin is affected by time and the elements. Diminished levels of this protein cause your skin to wrinkle and sag.

Keratin: This dominant protein in your skin makes up hair, nails and the surface layer of the skin. Keratin is what forms the rigidity of your skin.

Organ of sight

Hydrated collagen can be found in lenses.
Together with polysaccharides it forms the optic disc.
Natural Collagen enhances visual acuity when applied on eye-lids.

Hair

Collagen constitutes the supporting material of hair follicles. Collagen pigment is identical with hair pigment.

Natural Collagen restore beauty to the hair - gray hair gets darker, brows and eye lashes start growing again.

Bones

Classic example - like skin - of type I collagen occurrence in human body. Together with calcium and phosphorus salts type I collagen constitutes the bone building material. It forms 95% of bone matrix. It undergoes all physiological changes, life biological cycles, diseases, and diets.

Nerves and vessels

Collagen is a component of nerve fiber myelin sheath, spinal cord, brain meninges, and nerve cell basement membranes. Vessels - arterial, venous, lymphatic.

Alimentary tract

Type II and III collagen is the scaffold

supporting stomach, intestine and

esophagus parietal cells.

Collagen in menopause

The decrease of collagen turnover in women in perimenopausal period causes a number of diseases of the bone system and genitals. In urinary-genital system the disturbances of genital and urinary tracts trophiecs and statics are most common.

Discussing collagen deficit in women in this period of their lives, C. Falconer stresses that commonly used hormone replacement therapy results in the increase of hydrated type II and III collagen store in the urinary-genital system. Falconer has also shown that a number of dysfunctions, e.g. genital organ lowering, mucous membrane dryness, urinary incontinence, and inflammatory states, are caused by the change of collagen quantity and quality. The lack or small production volume of type II and III collagen by connective tissue cells cause the deficit of hydrated collagen in extracellular space. In such case the supply of estrogens results in a dramatic improvement.

We should know that collagen is the most powerful protein in our system. The name collagen is derived from Greek and means healing, bonding. Its highest quantities occur in the skeletal system, the skin, organ of sight, the kidneys, liver, alimentary tract. The extracellular fluid in which we are submerged consists of collagen, which flows around the organs, supplementing existing structural defects.

Collagen is produced in the cells of connective tissues, fibroblasts and in chondrocytes of the bone tissue. Sexual hormones, the growth hormone and growth factors, adrenal cortex and thyroid hormones participate in its biosynthetic process. The turnover of collagen occurs throughout our lives. What has been worn out degrades and shortages are being replaced immediately, just as in the aging process degeneration dominates over its synthesis in the skeletal system.

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These statements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure or prevent any disease.

We don't recommend using Natural Collagen Q5-26 products if you are pregnant, allergic to fish protein, undergoing radiotherapy, chemotherapy, kidney dialysis, or have connective skin disease (collagenosis).